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Evidence is increasing that addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight naturally can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you ought to err along the side of caution and allow FDA do its job and demand some research be done so that the public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies have been in business to earn money and that they would say almost anything to keep people on their own medications.

Researchers discovered that participants investing in this drug for any year, lost excess weight within a month and have kept the body weight off throughout the 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more efficient and safer.

Combo-pilling could be the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular may be the fact that by right now there aren't any long term prescription diet pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise blood pressure and heartbeat, and really should not be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must 't be used in patients with uncontrolled high hypertension, as well as by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.


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